His secular name was Giovanni Angelo Medici di Marignano; He/She was born in Milan (1499) and died in Rome (1565). He/She was the son of Bernardino Médici and Cecilia Serbelloni, of humble origins and little fortune, unrelated to the Medicis of Florence surname. He/She began his military career in Pavia and ended it in Bologna, gaining a solid reputation of jurist and philosopher. He/She embraced the ecclesiastical career and finished it at age 28. In 1527 he/she arrived in Rome and Pope Clement VII appointed him Protonotary and Paul III confirmed him in the same craft and then appointed him Governor of Ascoli Citta-di-Castello. It then conducted various missions for this Pope and was appointed successively Governor of Ancona, Archbishop of Ragusa, Governor of Perugia and cardinal priest with the title of santa Prudenciana, in 1549. Their relationship with Paulo IV were not friendly, electing the cardinal Médici a voluntary exile, which sweetened with literary occupations and works of charity. On the death of Paulo IV, ascended to the papal throne in 1559. He/She was a man of sweet character, which contributed to the Catholic reformation without the severity of his predecessor Paulo IV. Although he/she practiced nepotism as well as the previous pontiffs, this had a positive impact in the Church, at least in the case of the appointment as cardinal to San Carlos Borromeo, which contributed to the success of the Council of Trent and carried out far-reaching enterprises in favour of Christianity. He/She made several important works in the eternal city, founding the Roman Seminary and beautifying the city with sumptuous buildings, such as the monastery of la Cartuja, the Church of Santa María de Ángeles, the Palace of the academies in the Capitol, the office of impressions in the Vatican, the Pia door, work of Miguel Ángel, Angelica, in commemoration of his nameÁngel; He/She opened new streets, he/she built the Borgo Pio, restored Villa Julia, continued the work of building the Church of the Vatican, etc. In many of these works employed Miguel Ángel, who remunerated, honoured and encouraged as he/she could. In foreign policy, he/she took measures against Soliman, uniting his army of Felipe II, spending large sums in this war. In 1565, few months before his death was discovered an attempt on his life. After escape, he/she fell ill with a fever and died in December, 1565, after a pontificate of nearly six years. He/She was buried in the basilica of San Pedro, and his remains were moved in 1583 to the Church of Santa María de los Ángeles. Pius Vsucceeded him.